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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Inflammatory Bowel Disease II: Crohn's Disease

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Updated: May 13, 2026

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
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Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

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[IgG4-related disease].

J Loock1, B Manger

  • 1Klinik für Rheumatologie und klinische Immunologie, Schön Klinikum Hamburg Eilbek, Dehnhaide 120, 22081, Hamburg, Deutschland. jloock@schoen-kliniken.de

Zeitschrift Fur Rheumatologie
|March 6, 2013
PubMed
Summary
This summary is machine-generated.

Immunoglobulin G4-related disease (IgG4-RD) is a complex inflammatory condition. While treatable with steroids, relapses are common, and novel therapies like rituximab show promise for refractory cases.

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Area of Science:

  • Immunology
  • Rheumatology
  • Pathology

Context:

  • IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory syndrome with unknown causes.
  • It presents with inflammatory swelling and tumefactive lesions across multiple organs.
  • Recent advancements include diagnostic criteria and international consensus on histopathology.

Purpose:

  • To summarize the current understanding and management of IgG4-related disease.
  • To highlight challenges in treatment and long-term patient care.

Summary:

  • IgG4-RD activity is often controlled by high-dose prednisolone, but frequent relapses occur during steroid tapering.
  • Steroid-sparing agents show limited efficacy.
  • Rituximab has demonstrated success in refractory cases.
  • Persistent inflammation can lead to irreversible organ damage.

Impact:

  • Early diagnosis and appropriate management are crucial to prevent organ damage.
  • Long-term monitoring is necessary due to a potential increased risk of malignancies.
  • Further research into effective, long-term therapeutic strategies is warranted.