Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Work and work exposures in sugarcane farming in Eswatini, Southern Africa.

International archives of occupational and environmental health·2025
Same author

Supercomputer-Based Ensemble Docking Drug Discovery Pipeline with Application to Covid-19.

Journal of chemical information and modeling·2020
Same author

Supercomputer-Based Ensemble Docking Drug Discovery Pipeline with Application to Covid-19.

ChemRxiv : the preprint server for chemistry·2020
Same author

Physician burnout, work engagement and the quality of patient care.

Occupational medicine (Oxford, England)·2017
Same author

Equilibrium Dynamics in the Thallium(III)-Cyanide System in Aqueous Solution.

Inorganic chemistry·2016
Same author

Intervention to reduce heat stress and improve efficiency among sugarcane workers in El Salvador: Phase 1.

Occupational and environmental medicine·2016
Same journal

[Treatment of Vocal Fold Paralysis].

Zentralblatt fur Chirurgie·2026
Same journal

Zentralblatt fur Chirurgie·2026
Same journal

Predictive Factors for Mediastinal Lymph Node Metastases in Patients with Non-small Cell Lung Cancer, as Detected by Video-assisted Mediastinoscopic Lymphadenectomy.

Zentralblatt fur Chirurgie·2026
Same journal

[Robotic Management of a Bile Leak After Cholecystectomy Caused by an Aberrant Bile Duct of the Hepatic Segments, Using a Combined Biliodigestive Anastomosis Incorporating the Cystic Duct Stump].

Zentralblatt fur Chirurgie·2026
Same journal

[Microvascular Reconstruction of the Laryngotracheal Junction].

Zentralblatt fur Chirurgie·2026
Same journal

[Evaluation of Multimodal Perioperative Care Pathway Supported by a Patient-facing Mobile App in Colorectal Surgery - First Clinical Experience and Patient Satisfaction].

Zentralblatt fur Chirurgie·2026
See all related articles

Related Experiment Videos

[Gastrointestinal bleeding in the elderly].

J Glaser1

  • 1Innere Medizin, Herz-Jesu-Krankenhaus, Fulda, Deutschland.

Zentralblatt Fur Chirurgie
|March 6, 2013
PubMed
Summary
This summary is machine-generated.

Peptic ulcer disease is a common cause of gastrointestinal bleeding across all ages. For older adults, preventive proton pump inhibitor therapy is recommended with NSAID/aspirin use to reduce bleeding risks.

Related Experiment Videos

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Geriatrics

Context:

  • Peptic ulcer disease is a frequent cause of gastrointestinal bleeding, affecting patients irrespective of age.
  • Gastrointestinal bleeding incidence, particularly lower GI bleeding from diverticula and angiodysplasia, increases with age.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin are significant risk factors for both upper and lower gastrointestinal bleeding.

Purpose:

  • To highlight the importance of age-related gastrointestinal bleeding risks.
  • To recommend preventive strategies for elderly patients.
  • To outline diagnostic and therapeutic approaches for gastrointestinal bleeding in older adults.

Summary:

  • In patients aged 65 and older, concurrent proton pump inhibitor (PPI) therapy is advised when taking NSAIDs or aspirin to prevent ulcer bleeding.
  • Endoscopy is crucial for diagnosing gastrointestinal bleeding in the elderly, enabling direct endoscopic therapeutic interventions.
  • For elderly patients with comorbidities experiencing recurrent bleeding or continuous blood loss despite endoscopic therapy, timely consideration of surgery or transarterial embolization is essential.

Impact:

  • Provides evidence-based recommendations for managing gastrointestinal bleeding in aging populations.
  • Emphasizes the role of preventive pharmacotherapy and timely endoscopic interventions.
  • Guides clinical decision-making for advanced treatments like surgery or embolization in complex cases.