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Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

Tumour necrosis factor in infectious disease

John P Waters1, Jordan S Pober, John R Bradley

  • 1Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

The Journal of Pathology
|March 6, 2013
PubMed

Insights

Tumor necrosis factor (TNF) signals through TNFR1 and TNFR2 receptors, influencing cell functions and immune responses. Understanding TNF signaling is crucial for managing infectious diseases and related inflammatory conditions.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Medicine

Background:

  • Tumor necrosis factor (TNF) is a key cytokine involved in immune and inflammatory responses.
  • TNF exerts its effects through two receptors: TNFR1 and TNFR2.
  • Dysregulated TNF signaling contributes to tissue injury and systemic effects during infections.

Purpose of the Study:

  • To elucidate the molecular mechanisms of TNF signaling.
  • To investigate the impact of genetic diversity on TNF responses.
  • To understand the role of TNF blockade in infectious diseases.

Main Methods:

  • Analysis of TNF signaling pathways.
  • Examination of genetic variations in TNF signaling components.
  • Evaluation of therapeutic TNF blockade strategies.

Main Results:

  • TNF signaling regulates critical cellular processes including survival, proliferation, and cell death.
  • Genetic variations in TNF signaling influence disease susceptibility and outcome.
  • Therapeutic TNF blockade offers insights into TNF's role in infection.

Conclusions:

  • TNF signaling is a critical regulator of host defense and inflammation.
  • Understanding TNF's complex role is vital for developing effective treatments for infectious and inflammatory diseases.

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