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08:19
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Tumour necrosis factor and cancer
John P Waters1, Jordan S Pober, John R Bradley
1Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
The Journal of Pathology
|March 6, 2013
Summary
Tumour necrosis factor (TNF) has diverse roles in cancer, from killing cancer cells to promoting their survival and spread. Understanding its complex signalling pathways is key for developing targeted cancer therapies.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Tumour necrosis factor (TNF) was initially identified for its anti-tumour properties.
- Emerging evidence highlights TNF's multifaceted roles in cancer biology.
Purpose of the Study:
- To elucidate the complex functions of TNF in cancer.
- To explore the potential for targeted TNF signalling in cancer treatment.
Main Methods:
- Review of existing literature on TNF functions in cancer.
- Analysis of TNF-induced cellular responses and signalling pathways.
Main Results:
- TNF exhibits dual roles: inducing cancer cell death and promoting cancer cell survival, proliferation, migration, and invasion.
- TNF influences tumour microenvironment by triggering inflammatory cell infiltration and angiogenesis.
- Diverse cellular responses to TNF are mediated through distinct signal transduction pathways.
Conclusions:
- TNF's complex and context-dependent effects necessitate a nuanced understanding for therapeutic strategies.
- Targeting specific TNF signalling pathways offers a promising avenue for selective cancer therapy.
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