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The Influence of Liver Resection on Intrahepatic Tumor Growth
Published on: April 9, 2016
Use of pre-operative steroids in liver resection: a systematic review and meta-analysis
Arthur J Richardson1, Jerome M Laurence, Vincent W T Lam
1Department of Surgery, Westmead Hospital, Sydney, NSW, Australia; Discipline of Surgery, University of Sydney, Sydney, NSW, Australia.
Background:
By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications.
Methods:
A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed.
Results:
Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance.
Conclusion:
Pre-operative steroids may be associated with a clinically significant benefit in liver resection.
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