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Related Concept Videos

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Published on: February 13, 2016

Remotely controlled diffusion from magnetic liposome microgels.

Jaroslav Hanuš1, Martin Ullrich, Jiří Dohnal

  • 1Department of Chemical Engineering, Institute of Chemical Technology, Prague, Czech Republic.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 7, 2013
PubMed
Summary
This summary is machine-generated.

This study demonstrates contactless control over drug release from liposomes using radio-frequency magnetic fields. Iron oxide nanoparticles within hydrogel microparticles generate heat, enabling precise, on-demand payload diffusion.

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Area of Science:

  • Biomaterials Engineering
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Phospholipid bilayer permeability is temperature-dependent, offering a mechanism for controlling molecular payload diffusion from liposomes.
  • Liposomes are versatile carriers for molecular payloads but require controlled release mechanisms.
  • Hydrogel microparticles offer a matrix for immobilizing liposomes and other functional components.

Purpose of the Study:

  • To develop a contactless method for controlling the diffusion rate of encapsulated payloads from liposomes.
  • To integrate liposomes with iron oxide nanoparticles in calcium alginate hydrogel microparticles for temperature-controlled release.
  • To investigate the feasibility of on-demand and repeated payload release using radio-frequency (RF) magnetic fields.

Main Methods:

  • Fabrication of composite microparticles using a drop-on-demand inkjet method, incorporating liposomes, calcium alginate, and iron oxide nanoparticles.
  • Utilizing the heat dissipation of iron oxide nanoparticles under an RF alternating magnetic field to locally control temperature.
  • Investigating the internal structure of the composite microparticles and the influence of microparticle concentration on heating rates.

Main Results:

  • Successful immobilization of liposome-loaded fluorescent dye within alginate-magnetite microparticles.
  • Demonstrated contactless, RF-controlled, temperature-dependent payload diffusion from liposomes.
  • Achieved various release patterns, including repeated on-demand release, by modulating the RF field.
  • Determined that a minimum concentration of 25% maximum packing density for alginate beads is necessary for effective liposome membrane melting.

Conclusions:

  • The developed composite microparticles enable precise, contactless control over liposomal payload release via RF-induced heating.
  • This technology offers a promising platform for on-demand drug delivery systems with tunable release kinetics.
  • Optimizing microparticle concentration is crucial for achieving the desired temperature-triggered release profile.