Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iceball Margin <5 mm Is Associated with Local Failure after CT-guided Cryoablation of cT1a Renal Cell Carcinoma.

Journal of vascular and interventional radiology : JVIR·2026
Same author

Rare manifestations of tuberous sclerosis complex: low-grade oncocytic tumour and diffuse lipomatosis.

BMJ case reports·2025
Same author

[Renal tumours].

Ugeskrift for laeger·2025
Same author

ERN GENTURIS clinical practice guidelines for the diagnosis, surveillance and management of people with Birt-Hogg-Dubé syndrome.

European journal of human genetics : EJHG·2024
Same author

Pulmonary embolisms and infections after renal trauma.

Danish medical journal·2023
Same author

Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database.

EClinicalMedicine·2023
Same journal

Translation of the Breathing Vigilance Questionnaire for respiratory diseases.

Danish medical journal·2026
Same journal

Consensus on key concepts in audiometry.

Danish medical journal·2026
Same journal

Translation and validation of the Lee Chronic Graft-versus-Host Disease Symptom Scale in Denmark.

Danish medical journal·2026
Same journal

Variation in microbiological test requisitions among general practices in the North Denmark Region.

Danish medical journal·2026
Same journal

Diagnostic accuracy of common infectious disease discharge diagnoses from emergency department.

Danish medical journal·2026
Same journal

Minimally invasive ventral mesh rectopexy.

Danish medical journal·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
03:19

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition

Published on: June 21, 2024

Urinary biomarkers in hydronephrosis.

Mia Gebauer Madsen1

  • 1Department of Urology, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark. miagebauermadsen@ki.au.dk

Danish Medical Journal
|March 7, 2013
PubMed
Summary
This summary is machine-generated.

This study identified potential urinary biomarkers, EGF and MCP-1, for predicting kidney damage in newborns with hydronephrosis and ureteropelvic junction obstruction (UPJO). These biomarkers could aid in surgical intervention decisions for obstructive nephropathy.

More Related Videos

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Related Experiment Videos

Last Updated: May 13, 2026

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
03:19

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition

Published on: June 21, 2024

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Area of Science:

  • Nephrology
  • Pediatric Urology
  • Biomarker Discovery

Background:

  • Hydronephrosis affects 0.5-1% of newborns, with UPJO in 35% of cases, potentially leading to severe kidney damage.
  • Current management of UPJO relies on imaging and renograms, lacking reliable biomarkers for timely surgical intervention.
  • Identifying children needing early surgery versus watchful waiting is crucial for preserving renal function.

Purpose of the Study:

  • To investigate cytokine profiles in experimental hydronephrosis (Study I).
  • To identify and validate urinary biomarkers for diagnosing and predicting renal damage in pediatric UPJO (Study II).

Main Methods:

  • Study I: Analyzed urine and kidney cytokine levels (IL-1β, IL-6, TNF-α, IL-10) in rat models of acute and chronic unilateral ureteral obstruction.
  • Study II: Measured urinary protein concentrations (EGF, IP-10, MCP-1, RANTES, MIP-1α, NGAL, CyC, βM-2, OPN) in children with UPJO before and after surgery, comparing them to healthy controls.

Main Results:

  • Acute obstruction in rats showed altered renal and urinary cytokine levels (IL-1β, IL-6, TNF-α, IL-10); chronic obstruction showed only altered urinary IL-6.
  • Children with UPJO exhibited significantly higher urinary EGF and MCP-1 levels, which decreased post-surgery.
  • Urinary protein concentrations correlated with obstruction severity, age, and differential renal function (DRF).

Conclusions:

  • Urinary EGF and MCP-1 show potential as biomarkers for hydronephrosis and UPJO, reflecting obstruction status.
  • Urinary cytokine profiles differ between acute and chronic experimental hydronephrosis.
  • Further research is needed to establish these proteins as reliable clinical tools for managing obstructive nephropathy.