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Related Concept Videos

Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

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Related Experiment Video

Updated: May 13, 2026

Fixation of Embryonic Mouse Tissue for Cytoneme Analysis
08:46

Fixation of Embryonic Mouse Tissue for Cytoneme Analysis

Published on: June 16, 2022

EMT in developmental morphogenesis.

Yukiko Nakaya1, Guojun Sheng

  • 1Lab for Early Embryogenesis, RIKEN Center for DevelopmentalBiology, 2-2-3 Minatojima-minamimachi, Chuo-Ku, Kobe, Hyogo 650-0047, Japan.

Cancer Letters
|March 7, 2013
PubMed
Summary
This summary is machine-generated.

Carcinomas involve epithelial-mesenchymal transition (EMT), a process also crucial in normal development. Studying developmental EMT offers insights into diverse cancer progression mechanisms.

Keywords:
AmnioteBirdsCancerDevelopmental EMTEpitheliumMammalsMesenchymeStratificationVertebrate

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Last Updated: May 13, 2026

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Area of Science:

  • Developmental Biology
  • Cancer Biology
  • Cellular Biology

Background:

  • Carcinomas, cancers originating from epithelial cells, represent the most common cancer type.
  • Progression of carcinomas involves loss of epithelial traits, cell-cycle dysregulation, and enhanced cell migration.
  • Understanding the interplay between epithelial homeostasis, cell proliferation, and migration is key to cancer research.

Purpose of the Study:

  • To review the role of Epithelial-Mesenchymal Transition (EMT) in normal amniote development.
  • To explore how developmental EMT processes can inform our understanding of carcinoma progression.
  • To highlight the diversity of EMT in both development and cancer.

Main Methods:

  • Literature review focusing on developmental and morphogenetic processes involving EMT.
  • Analysis of 12 distinct developmental processes exhibiting EMT.
  • Comparative analysis of EMT in developmental contexts versus cancer.

Main Results:

  • EMT is a fundamental process in at least 12 normal amniote developmental and morphogenetic events.
  • Developmental EMT processes exhibit significant diversity in context and cellular morphogenesis.
  • Comparable diversity is proposed for cancer microenvironments and the molecular regulation of cancer EMTs.

Conclusions:

  • The study of EMT during embryonic development provides a framework for understanding carcinoma progression.
  • Recognizing the inherent diversity of EMT is crucial for both developmental and cancer research.
  • Further investigation into cancer-associated EMT may benefit from developmental biology paradigms.