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Related Experiment Video

Updated: May 13, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

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Published on: January 18, 2018

Perioperative interventions to reduce chronic postsurgical pain.

Ian Carroll¹, Jennifer Hah, Sean Mackey

¹Department of Anesthesiology, Division of Pain Management, Stanford School of Medicine, Palo Alto, CA, USA. irc39@pain.stanford.edu

Journal of Reconstructive Microsurgery

|March 7, 2013

Summary

Preventative analgesia, using perioperative interventions, can significantly reduce chronic postsurgical pain. Surgeons and anesthesiologists can implement evidence-based plans to lower pain incidence and severity.

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An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

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A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

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Published on: January 18, 2018

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Area of Science:

Pain Medicine
Surgical Oncology
Anesthesiology

Background:

Chronic postsurgical pain affects approximately 10% of patients after surgery.
Reconstructive surgeries, like breast and limb reconstruction, carry a higher risk.
Preventative analgesia strategies show promise in animal models for reducing chronic pain.

Purpose of the Study:

To explore the potential of perioperative interventions in preventing chronic postsurgical pain.
To highlight the role of surgeons and anesthesiologists in implementing preventative analgesia.
To translate findings from animal studies to human clinical practice.

Main Methods:

Review of animal studies demonstrating the efficacy of various interventions (e.g., local anesthetics, gabapentin) in reducing pain behaviors.
Analysis of recent clinical trial data on perioperative interventions.
Focus on the critical time frame before and immediately after nerve injury.

Main Results:

Animal models show that specific perioperative treatments can reduce chronic neuropathic pain behaviors.
Clinical data suggest a significant opportunity to reduce chronic postsurgical pain incidence and severity.
Evidence supports the use of brief perioperative interventions to prevent long-term pain.

Conclusions:

Perioperative interventions can effectively reduce the incidence and severity of chronic postsurgical pain.
Surgeons and anesthesiologists can collaborate to implement evidence-based preventative analgesia plans.
Translating animal study findings to human practice offers a promising approach to pain management.