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Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Risk stratification and consecutive prognosis progresses in childhood Wilms tumors. Two cases report
S Diaconescu1, C Olaru, D Mihailă
1Vth Pediatric Clinic, Emergency Clinic Children Hospital "St Mary", "Gr T Popa" University of Medicine and Pharmacy Iaşi, Romania.
Chirurgia (Bucharest, Romania : 1990)
|March 8, 2013
Summary
Wilms tumor, a common childhood cancer, can be effectively treated with preoperative chemotherapy and surgery. Early diagnosis through ultrasonography and CT scans, followed by SIOP-protocol treatment, led to successful outcomes in two young patients.
Area of Science:
- Pediatric Oncology
- Nephrology
- Diagnostic Imaging
Background:
- Wilms tumor is the most common pediatric malignancy.
- Delayed diagnosis and specific risk factors present challenges.
- Therapeutic successes highlight the need for improved management strategies.
Observation:
- Two young girls presented with nonspecific symptoms like constipation and psychomotor disturbances.
- Abdominal ultrasonography incidentally detected renal masses in both cases.
- CT scans confirmed solid, encapsulated tumors suggestive of Wilms tumor.
Findings:
- Both patients received preoperative chemotherapy followed by nephrectomy, adhering to SIOP protocols.
- Pathology revealed triphasic nephroblastoma (intermediary risk) and stage IIb nephroblastoma with focal epithelial anaplasia.
- Both patients achieved a stable cure with disease-free periods of 23 and 24 months, respectively.
Implications:
- Preoperative chemotherapy is effective, well-tolerated, and reduces tumor volume and surgical risks.
- Nonspecific symptoms in children can mask serious conditions like Wilms tumor.
- Multimodal treatment integrating chemotherapy and surgery offers a promising approach for pediatric Wilms tumor.
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