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Rapid-antigen detection tests for group a streptococcal pharyngitis: revisiting false-positive results using
Jérémie F Cohen1, Robert Cohen, Philippe Bidet
1INSERM, UMR S953, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, Paris, France. jeremie.cohen@inserm.fr
Abstract:
We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.
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