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Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
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Outcome following neonatal seizures
Cristina Uria-Avellanal1, Neil Marlow, Janet M Rennie
1UCL EGA Institute for Women's Health, University College London, London, UK. c.uria@ucl.ac.uk
Seminars in Fetal & Neonatal Medicine
|March 8, 2013
Summary
Neonatal seizures in newborns are common neurological issues. While mortality has decreased, long-term neurodevelopmental problems persist, influenced by the cause and EEG activity.
Area of Science:
- Neonatal neurology
- Pediatric neurology
- Neurodevelopmental disorders
Background:
- Neonatal seizures are the most common neurological disorder in newborns.
- They significantly impact neurological outcomes.
- Mortality rates have improved, but adverse sequelae remain a concern.
Purpose of the Study:
- To review the current understanding of neonatal seizures.
- To discuss predictors of outcome.
- To propose a prognostic pathway for affected infants.
Main Methods:
- Literature review and synthesis of existing data.
- Analysis of mortality and neurodevelopmental sequelae trends.
- Identification of key prognostic indicators.
Main Results:
- Mortality for term infants with seizures has decreased from 33% (1990s) to 10% currently.
- Neurodevelopmental sequelae rates remain stable at approximately 46%.
- Underlying cause and electroencephalographic (EEG) activity are primary outcome predictors.
Conclusions:
- While mortality has improved, long-term neurodevelopmental impairments following neonatal seizures persist.
- Prognosis is influenced by the etiology and EEG background.
- A comprehensive assessment pathway is proposed for accurate risk communication.
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