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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Published on: October 25, 2018

Stemformatics: visualisation and sharing of stem cell gene expression.

Christine A Wells1, Rowland Mosbergen, Othmar Korn

  • 1The Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, 4072 Australia. c.wells@uq.edu.au

Stem Cell Research
|March 8, 2013
PubMed
Summary
This summary is machine-generated.

Stemformatics offers a public portal for sharing and visualizing stem cell data, addressing challenges in genomic data analysis. It also enables the creation and analysis of community-curated gene sets for stem cell research.

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Area of Science:

  • Stem cell biology
  • Genomics
  • Bioinformatics
  • Data visualization

Background:

  • Genome-scale technologies are vital for understanding stem cell states.
  • Sharing and visualizing diverse stem cell data present significant challenges.
  • Limited public pathways and gene lists hinder stem cell signature analysis.

Purpose of the Study:

  • To introduce Stemformatics, a user-friendly portal for stem cell data.
  • To facilitate data sharing, visualization, and analysis within the stem cell community.
  • To provide a repository for community-annotated gene sets relevant to stem cell biology.

Main Methods:

  • Development of a publicly accessible web portal (stemformatics.org).
  • Integration of diverse stem cell datasets from multiple laboratories.
  • Implementation of fast gene expression visualization tools.
  • Creation of a mechanism for users to generate, share, and analyze gene sets.

Main Results:

  • Stemformatics hosts a large collection of exemplar stem cell data.
  • The portal enables rapid visualization of gene expression across human and mouse datasets.
  • It provides transparent links to original research studies.
  • A repository of community-annotated stem cell gene lists is available for pathway and lineage analysis.

Conclusions:

  • Stemformatics effectively addresses challenges in stem cell data sharing and visualization.
  • The portal enhances the analysis of stem cell signatures through accessible data and community-driven gene sets.
  • It serves as a valuable resource for stem cell researchers, promoting collaborative data exploration.