Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophage-mediated brain-bone marrow crosstalk promotes chronic stress-induced glioma growth.

Cancer cell·2026
Same author

DVNDTA: a dual virtual node based heterogeneous interaction model for accurate prediction of drug-target affinity.

BMC bioinformatics·2026
Same author

Maternal Immune Activation Disrupts Epigenomic and Functional Maturation of Cortical Excitatory Neurons.

bioRxiv : the preprint server for biology·2026
Same author

Transient cell states encode positional information to direct asymmetric growth.

bioRxiv : the preprint server for biology·2026
Same author

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures.

bioRxiv : the preprint server for biology·2026
Same author

Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: May 13, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Patterns of population epigenomic diversity.

Robert J Schmitz1, Matthew D Schultz, Mark A Urich

  • 1Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Nature
|March 8, 2013
PubMed
Summary

Epigenetic variation in Arabidopsis thaliana influences traits, but its genetic basis is unclear. This study reveals how RNA-directed DNA methylation interacts with genetic variation to create diversity in plant populations.

More Related Videos

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

TChIP-Seq: Cell-Type-Specific Epigenome Profiling
07:28

TChIP-Seq: Cell-Type-Specific Epigenome Profiling

Published on: January 23, 2019

Related Experiment Videos

Last Updated: May 13, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

TChIP-Seq: Cell-Type-Specific Epigenome Profiling
07:28

TChIP-Seq: Cell-Type-Specific Epigenome Profiling

Published on: January 23, 2019

Area of Science:

  • Plant genomics and epigenetics
  • Population genetics and variation

Background:

  • Epigenetic variation contributes to phenotypic diversity, but its interplay with genetic variation needs clarification.
  • Understanding the genetic basis of epigenetic differences is crucial for explaining population-level variation.

Purpose of the Study:

  • To investigate the interaction between genetic and epigenetic variation in wild Arabidopsis thaliana.
  • To identify genetic factors influencing DNA methylation patterns and their contribution to phenotypic diversity.

Main Methods:

  • Population-wide sequencing of genomes, transcriptomes, and methylomes from wild Arabidopsis thaliana accessions.
  • Analysis of DNA methylation polymorphisms and their linkage to genetic variation.
  • Association studies to identify methylation quantitative trait loci (mQTLs).

Main Results:

  • Single cytosine methylation polymorphisms are not directly linked to genotype.
  • Regions targeted by RNA-directed DNA methylation show linkage disequilibrium decay similar to single nucleotide polymorphisms.
  • Thousands of mQTLs were identified, revealing genetically dependent methylation variation across the population.
  • RNA-directed DNA methylation targets are epigenetically activated in pollen and seeds.

Conclusions:

  • Genetic variation influences DNA methylation patterns, particularly those targeted by RNA-directed DNA methylation.
  • Epigenetic regulation via RNA-directed DNA methylation plays a role in plant development, especially in reproductive tissues.
  • This study provides insights into the genetic underpinnings of epigenetic variation and its role in population diversity.