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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...

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Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution
11:39

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution

Published on: September 21, 2012

Bone healing and mannose-binding lectin.

J Van der Ende1, L J Van Baardewijk, C F M Sier

  • 1Department of Trauma Surgery, Leiden University Medical Center, Leiden, Netherlands. vanderende.jacob@gmail.com

International Journal of Surgery (London, England)
|March 8, 2013
PubMed
Summary
This summary is machine-generated.

Mannose-Binding Lectin (MBL) deficiency may impede fracture healing by affecting bone remodeling. Early identification of MBL deficiency could enable preventive strategies for fracture non-union.

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Area of Science:

  • Orthopedics
  • Immunology
  • Biochemistry

Background:

  • Fracture healing involves inflammation, reconstruction, and remodeling phases.
  • The complement system and coagulation cascade are integral to bone healing.
  • The role of complement components in the remodeling phase remains unclear.

Purpose of the Study:

  • To review the role of Mannose-Binding Lectin (MBL) in bone healing.
  • To explore the consequences of MBL deficiency in fracture non-union.
  • To hypothesize MBL's influence on the remodeling phase of bone healing.

Main Methods:

  • Literature review of MBL's function in complement and coagulation.
  • Analysis of MBL's potential role in the bone healing cascade.
  • Discussion of genetic variations affecting MBL levels.

Main Results:

  • MBL and MASP-2 are involved in initiating the complement system and coagulation.
  • MBL deficiency may disrupt bone remodeling by affecting apoptotic cell clearance or fibrin scaffold formation.
  • Genetic variations leading to MBL deficiency are hypothesized to contribute to non-union.

Conclusions:

  • MBL likely plays a significant role in the remodeling phase of bone healing.
  • MBL deficiency may increase the risk of fracture non-union.
  • Early identification and intervention for MBL deficiency are crucial for preventing non-union.