[Energy of ion pairs in proteins]

The energy of ions interaction in an ionic pair and the energy of ions transfer from water into protein at different ions disposition relative to the protein/water boundary has been considered. Ultimately, the ions transfer from aqueous phase into protein, i. e. in the medium with a low dielectric constant is energetically unfavorable and hence it cannot stabilize the protein structure by itself. For stabilization of ionic pairs in protein the action of some additional factors is necessary, in particular the action of the intraglobular electric field.