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Updated: May 13, 2026
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Cubic phase nanoparticles for sustained release of ibuprofen: formulation, characterization, and enhanced
Linghui Dian1, Zhiwen Yang, Feng Li
1School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, People's Republic of China.
International Journal of Nanomedicine
|March 8, 2013
Summary
New ibuprofen-loaded cubic nanoparticles significantly enhance oral bioavailability. These novel nanoparticles improve drug absorption and prolong half-life, offering a promising delivery system for ibuprofen formulations.
Area of Science:
- Nanotechnology
- Pharmaceutics
- Drug Delivery Systems
Background:
- Improving oral bioavailability of poorly soluble drugs like ibuprofen is a significant challenge in pharmaceutical development.
- Conventional ibuprofen formulations can suffer from limited absorption and variable therapeutic outcomes.
Purpose of the Study:
- To develop and characterize ibuprofen-loaded cubic nanoparticles for enhanced oral drug delivery.
- To evaluate the in vitro release profile and in vivo pharmacokinetic performance of ibuprofen from these nanoparticles.
Main Methods:
- Preparation and characterization of ibuprofen-loaded cubic nanoparticles using cryogenic transmission electron microscopy, differential scanning calorimetry, and X-ray diffraction.
- In vitro drug release studies over 24 hours.
- Pharmacokinetic evaluation in beagle dogs comparing nanoparticles to pure ibuprofen.
Main Results:
- Cubic nanoparticles exhibited an encapsulation efficiency >85% and a mean size of 238 nm.
- Ibuprofen was found in an amorphous, molecular state within the lipid matrix.
- Sustained in vitro release (>80% at 24 hours) and a 222% relative oral bioavailability in vivo were observed.
Conclusions:
- Ibuprofen-loaded cubic nanoparticles demonstrate a promising drug delivery system for improving oral bioavailability.
- The developed nanoparticles offer sustained release and enhanced pharmacokinetic properties for ibuprofen.
- This formulation represents an efficient carrier for therapeutic ibuprofen treatment.
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