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Updated: May 13, 2026
10:03
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Copeptin adds prognostic information after ischemic stroke: results from the CoRisk study
Gian Marco De Marchis1, Mira Katan, Anja Weck
1Department of Neurology, Neuroradiology, and Clinical Chemistry, Inselspital, University of Bern, Switzerland.
Neurology
|March 8, 2013
Summary
Copeptin, a blood marker, accurately predicts outcomes and complications in acute ischemic stroke patients. It improves predictions beyond established clinical variables like stroke severity and age.
Area of Science:
- Neurology
- Biomarkers
- Stroke Medicine
Background:
- Accurate prediction of outcomes and complications in acute ischemic stroke is crucial for patient management.
- Established clinical variables may not fully capture the risk profile of stroke patients.
Purpose of the Study:
- To evaluate the incremental predictive value of copeptin compared to established clinical variables for stroke outcomes and complications.
- To validate copeptin as a prognostic biomarker in acute ischemic stroke.
Main Methods:
- Prospective, multicenter, cohort study of 783 acute ischemic stroke patients.
- Copeptin levels measured in emergency room within 24 hours of symptom onset.
- Primary endpoints: unfavorable functional outcome and mortality at 90 days; Secondary endpoints: in-hospital complications.
Main Results:
- Higher copeptin levels independently predicted unfavorable outcome, mortality, and complications.
- Adding copeptin significantly improved discriminatory accuracy for all endpoints.
- Copeptin combined with NIH Stroke Scale and age improved reclassification for functional outcome and mortality.
Conclusions:
- Copeptin is a validated blood marker that provides additional predictive information for functional outcome and mortality in ischemic stroke patients.
- Copeptin shows promise as a novel biomarker for predicting in-hospital complications.
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