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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...

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Related Experiment Video

Updated: May 13, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

MicroRNAs and the heart: small things do matter.

Nikolaos Papoutsidakis1, Spyridon Deftereos, Andreas Kaoukis

  • 1Cardiology Department and Cardiac Catheterization Laboratory, Athens General Hospital G. Gennimatas, Athens, Greece. npapouts2@gmail.com

Current Topics in Medicinal Chemistry
|March 9, 2013
PubMed
Summary

MicroRNAs regulate gene expression and are vital in cardiovascular health and disease. This review summarizes their function, and potential as biomarkers and therapeutic targets in cardiovascular conditions.

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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

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Last Updated: May 13, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Science

Background:

  • MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression.
  • They are found in most eukaryotic cells and play critical roles in cellular processes.
  • Emerging research highlights their significance in human physiology and pathology.

Purpose of the Study:

  • To review the current understanding of microRNA expression, regulation, and function in cardiovascular diseases.
  • To discuss the potential of microRNAs as novel biomarkers for cardiovascular conditions.
  • To explore the therapeutic applications of microRNAs in treating cardiovascular diseases.

Main Methods:

  • Literature review of current research on microRNAs in cardiovascular disease.
  • Synthesis of information on microRNA biogenesis, function, and regulation.
  • Analysis of studies investigating microRNAs as biomarkers and therapeutic targets.

Main Results:

  • MicroRNAs are key regulators of cardiovascular system development and function.
  • Dysregulation of microRNAs is implicated in various cardiovascular diseases.
  • Specific microRNAs show promise as indicators of disease state and therapeutic targets.

Conclusions:

  • MicroRNAs are integral to cardiovascular health and disease pathogenesis.
  • Further research into microRNAs could lead to significant advancements in cardiovascular diagnostics and therapeutics.
  • MicroRNAs represent a promising frontier for future cardiovascular medicine.