Related Experiment Video
Updated: May 13, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
Psychosocial distress as a risk factor of ischemic heart disease mortality
1Grodno State Medical University, Grodno, Belarus. yury_razvodovsky@mail.ru
Insights
Psychosocial distress significantly impacts ischemic heart disease (IHD) mortality rates. Russia
Area of Science:
- Public Health
- Epidemiology
- Cardiology
Background:
- Ischemic heart disease (IHD) is a leading cause of death globally.
- Psychosocial distress is increasingly recognized as a risk factor for IHD.
- Societal changes, like those in 1990s Russia, may exacerbate IHD mortality.
Purpose of the Study:
- To investigate the association between psychosocial distress and IHD mortality in Russia.
- To analyze the impact of societal transformation on cardiovascular health outcomes.
Main Methods:
- Utilized time series analysis of age-adjusted, sex-specific suicide rates (as a proxy for psychosocial distress) and IHD mortality in Russia (1965-2005).
- Employed distributed lags analysis to assess the bivariate relationship between the two time series.
Main Results:
- Found a statistically significant association between psychosocial distress indicators and IHD mortality.
- Identified significant relationships at lag 0 for males and lags 0 and 1 for females.
Conclusions:
- The Russian IHD mortality crisis is likely linked to psychosocial distress from rapid societal transformation.
- Societal-level changes can profoundly influence population health, serving as a critical public health concern.
Background:
Ischemic heart disease (IHD) is the leading cause of morbidity and mortality in the industrialized world. Recent research evidence suggests that psychosocial distress has been implicated as both a precursor to IHD and a significant risk factor for death in those with established IHD. According to WHO, psychosocial distress will be the most harmful risk factor for the development of IHD in the near future. Some experts have underlined the importance of the psychosocial distress of economic and political reforms as the main reason for the IHD mortality crisis in Russia in the 1990s. The aim of the present study was to estimate the effect of psychosocial distress on IHD mortality rate in Russia.
Subjects And Methods:
Trends in age-adjusted, sex-specific suicide (as an integral indicator for psychosocial distress) and IHD mortality rate in Russia from 1965 to 2005 were analyzed employing a distributed lags analysis in order to assess the bivariate relationship between the two time series.
Results:
Time series analysis indicates the presence of a statistically significant association between the two time series for males at lags 0 and females at lags 0 and 1.
Conclusions:
These findings suggest that the Russian IHD mortality crisis is most likely to have been precipitated by the psychosocial distress imposed by rapid societal transformation. The experience of Russia should serve as an example of how societal-level change can influence the health of a population.
Related Concept Videos
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Coronary Artery Disease I: Introduction
Coronary Artery Disease IV: Preventive Measures
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Acute Coronary Syndrome IV: Interprofessional Care
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
