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POPULATION GENETICS OF NEUTRAL MUTATIONS IN EXPONENTIALLY GROWING CANCER CELL POPULATIONS

Rick Durrett1

  • 1DEPARTMENT OF MATHEMATICS DUKE UNIVERSITY BOX 90320 DURHAM, NORTH CAROLINA 27708-0320 USA rtd@math.duke.edu.

The Annals of Applied Probability : an Official Journal of the Institute of Mathematical Statistics
|March 9, 2013
PubMed
Summary

Distinguishing cancer driver mutations from neutral passenger mutations is crucial. This study analyzes neutral mutation frequencies in branching processes, providing a new population genetics model for cancer genome data.

Keywords:
Exponentially growing populationcancer modelmultitype branching processsite frequency spectrum

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