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Evaluation of structural and functional changes in non-pathologic myopic fundus using multifocal electroretinogram
Saemi Park1, Seung Hoon Kim, Tae Kwann Park
1Department of Ophthalmology, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital, #1174 Jung-dong, Wonmi-gu, Bucheon 420-767, Korea.
Documenta Ophthalmologica. Advances in Ophthalmology
|March 9, 2013
Summary
Structural and functional retinal changes in myopia correlate with increasing refractive error. Spectral domain-optical coherence tomography and multifocal electroretinography reveal significant thinning and altered electrical responses, particularly in high myopia.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Vision Science
Background:
- Myopia is a common refractive error with potential structural and functional retinal alterations.
- Understanding these changes is crucial for managing myopia progression and associated complications.
Purpose of the Study:
- To investigate the relationship between refractive error and retinal structural/functional changes in non-pathologic myopia.
- To utilize multifocal electroretinography (mfERG) and spectral domain-optical coherence tomography (SD-OCT) for this evaluation.
Main Methods:
- Ninety myopic subjects were categorized into four groups based on refractive error.
- SD-OCT measured retinal thickness (total, photoreceptor, mid-inner retinal layers).
- mfERG analyzed electrical response amplitudes and implicit times.
Main Results:
- Progressive myopia correlated with reduced photoreceptor and mid-inner retinal thickness.
- Significant correlations were found between refractive error and mfERG amplitudes/implicit times.
- Mid-inner retinal thickness showed significant correlations with mfERG parameters in the perifoveal region.
Conclusions:
- A strong correlation exists between structural and functional retinal changes in myopia.
- These findings are particularly relevant for interpreting results in high myopia cases.
- Integrated use of SD-OCT and mfERG provides comprehensive insights into myopic retinal alterations.
