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Genotype variation of hepatitis C virus in District Buner Swat

Khalid Mahmood1, Noor Mohammad, Abidullah

  • 1Department of Medicine, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar, Pakistan. Khalidm30@hotmail.com

Journal of Ayub Medical College, Abbottabad : JAMC
|March 12, 2013
PubMed

Insights

Hepatitis C virus (HCV) genotype 3, particularly subtypes 3a and 3b, is the most prevalent in District Buner, Swat. This study determined the frequency of various HCV genotypes in the region.

Area of Science:

  • Virology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection is a significant global health concern.
  • Understanding the distribution of HCV genotypes is crucial for effective treatment and prevention strategies.
  • Genotype prevalence varies geographically, impacting treatment outcomes.

Purpose of the Study:

  • To ascertain the frequency of different Hepatitis C virus genotypes in District Buner, Swat.
  • To provide epidemiological data on HCV genotype distribution in this specific region of Pakistan.
  • To inform public health initiatives and clinical management of HCV.

Main Methods:

  • A descriptive case series study was conducted from January 2007 to June 2008.
  • 400 patients with confirmed HCV infection (positive antibodies and RNA) were enrolled.
  • Hepatitis C virus genotypes were identified using real-time Polymerase Chain Reaction (RT-PCR).

Main Results:

  • Genotype 3 was the most common (61.5%), with subtypes 3a (45.5%) and 3b (16%) being most frequent.
  • Genotype 1a (8.7%) and 1b (3%) were also identified.
  • Mixed infections were observed in 16% of patients, with other genotypes (2a, 2b, 4a, 6a) found at lower frequencies.

Conclusions:

  • Hepatitis C virus genotype 3, specifically subtypes 3a and 3b, is the predominant genotype in District Buner, Swat.
  • Genotype 1a and 2a, along with mixed infections, were the next most frequent.
  • These findings highlight the importance of regional genotype surveillance for HCV management.
Abstract

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