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Carboxamide versus sulfonamide in peptide backbone folding: a case study with a hetero foldamer
Veera V E Ramesh1, Sangram S Kale, Amol S Kotmale
1Division of Organic Chemistry, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
Abstract:
Strikingly dissimilar hydrogen-bonding patterns have been observed for two sets of closely similar hetero foldamers containing carboxamide and sulfonamides at regular intervals. Although both foldamers maintain conformational ordering, the hydrogen-bonding pattern and backbone helical handedness differ diametrically.
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