Related Experiment Video
Updated: May 13, 2026
11:13
Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
Published on: April 5, 2016
Illuminating hippocampal control of fear memory and anxiety
Neil M Fournier1, Ronald S Duman
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA.
Neuron
|March 12, 2013
Abstract:
Previous reports on dorsal and ventral hippocampal regulation of context learning versus anxiety have been mixed. In this issue of Neuron, a new study by Kheirbek et al. (2013) using optogenetics demonstrates that dentate gyrus granule cell activity in dorsal hippocampus encodes contextual fear learning while ventral granule cell activity regulates anxiety behavior.
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