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Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
Published on: March 22, 2022
Laboratory evaluation of the Coasys® Plus C coagulation analyzer
Prim de Bie1, Willem J Schornagel, Erik-Jan van den Dool
1Laboratory for General Clinical Chemistry, Academic Medical Centre, University of Amsterdam, the Netherlands.
Thrombosis Research
|March 12, 2013
Summary
The Coasys® Plus C analyzer demonstrates suitable analytical performance for clinical chemistry labs, showing good precision and correlation for most coagulation tests. However, D-Dimer analysis showed insufficient correlation with a reference system.
Area of Science:
- Clinical Chemistry
- Hematology
- Laboratory Medicine
Background:
- The Coasys® Plus C is a coagulation analyzer designed for small to midsize clinical laboratories.
- Laboratory evaluations are crucial for assessing the performance of new diagnostic instruments.
Purpose of the Study:
- To evaluate the laboratory performance of the Coasys® Plus C coagulation analyzer.
- To assess key analytical parameters including dead volume, carry-over, capacity, reproducibility, and imprecision.
- To compare its performance with a established system, the STA-R Evolution®.
Main Methods:
- Evaluated dead volume, carry-over, capacity, within-assay reproducibility, and imprecision for multiple coagulation tests.
- Conducted precision tests and patient comparisons against the STA-R Evolution® system.
- Included tests such as activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen, antithrombin, and D-Dimer.
Main Results:
- The Coasys® Plus C analyzer exhibited no detected carry-over and an average throughput of 66 measurements per hour.
- Within-assay reproducibility and total imprecision varied across different tests, with generally acceptable performance for most.
- Good correlation was observed with the STA-R Evolution® for aPTT, PT, antithrombin, and fibrinogen, though some discrepancies were noted for extreme fibrinogen results.
- Insufficient correlation was found for D-Dimer analysis between the two systems.
Conclusions:
- The Coasys® Plus C analyzer is efficient, user-friendly, and safe for laboratory personnel.
- Its analytical performance profile indicates suitability for routine use in clinical chemistry laboratories.
- Specific attention may be needed for D-Dimer testing when using this analyzer in comparison to other systems.
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