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Updated: May 13, 2026

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images
Published on: November 15, 2024
Refining a region-of-interest within an available CT image
Esmaeil Enjilela1, Esam M A Hussein
1Laboratory for Threat Material Detection, Department of Mechanical Engineering, University of New Brunswick, Fredericton, NB, Canada E3B 5A3.
Abstract:
This paper describes a numerical method for refining the image of a region-of-interest (RoI) within an existing tomographic slice, provided that projection data are stored along with the image. Using the attributes of the image, projection values (ray-sums) are adjusted to compensate for the material outside the RoI. Advantage is taken of the high degree of overdetermination of common computed tomography systems to reconstruct an RoI image over smaller pixels. The smaller size of a region-of-interest enables the use of iterative methods for RoI image reconstruction, which are less prone to error propagation. Simulation results are shown for an anthropomorphic head phantom, demonstrating that the introduced approach enhances both the spatial resolution and material contrast of RoI images; without the need to acquire any additional measurements or to alter existing imaging setups and systems.

