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[Hormonal synergism, maturation of lung structure and surfactant production in the fetal sheep lung]
J C Schellenberg1, G C Liggins
1Postgraduate School of Obstetrics and Gynaecology, University of Auckland, New Zealand.
Gynakologische Rundschau
|January 1, 1990
Abstract:
Simultaneous administration of cortisol, triiodothyronine, and prolactin but not of any of these hormones infused singly or in combination of two, increases pulmonary distensibility and stability to term values in fetal sheep of 125 days gestation. Similar results are obtained with thyrotropin-releasing hormone and cortisol. Measurements of elastin and collagen and discrepancies between concentrations of alveolar surfactant and lung distensibility and stability suggest that maturation of connective tissue plays an important part in fetal lung maturation.