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Related Concept Videos

Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 13, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Proteomics imaging and the kidney.

Fulvio Magni1, Maciej Lalowski, Veronica Mainini

  • 1Department of Health Science, University of Milano-Bicocca, Monza, Italy. fulvio.magni@unimib.it

Journal of Nephrology
|March 12, 2013
PubMed
Summary
This summary is machine-generated.

Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging reveal molecular distribution in tissues. This review details MALDI profiling/imaging technologies and their kidney research applications.

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Area of Science:

  • Biomedical Imaging
  • Analytical Chemistry
  • Molecular Pathology

Background:

  • Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are powerful analytical techniques.
  • These technologies enable simultaneous spatial distribution analysis of diverse molecules within tissue specimens.
  • Applications span drug and metabolite localization, endogenous lipid profiling, and peptide/protein mapping.

Purpose of the Study:

  • To review MALDI profiling and imaging technologies.
  • To highlight their utility in molecular tissue analysis.
  • To provide examples of their application in kidney research.

Main Methods:

  • Description of MALDI profiling and imaging principles.
  • Discussion of data acquisition and analysis workflows.
  • Integration of MALDI imaging with other analytical and imaging modalities.

Main Results:

  • MALDI imaging provides high spatial resolution molecular information directly from tissue.
  • It allows for the simultaneous detection of multiple molecular classes.
  • Correlative analysis with other techniques enhances data interpretation.

Conclusions:

  • MALDI profiling and imaging are versatile tools for molecular tissue analysis.
  • These techniques offer significant advantages for understanding tissue composition and spatial organization.
  • Their application in kidney research provides valuable insights into renal pathophysiology.