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Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
18:08

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Published on: December 31, 2007

[NKT cells: their development, mechanisms and effects of action]

Agnieszka Bojarska-Junak1, Jacek Tabarkiewicz, Jacek Roliński

  • 1Katedra i Zakład Immunologii Klinicznej, Uniwersytet Medyczny w Lublinie, Lublin. agnieszkajunak@poczta.onet.pl

Postepy Higieny I Medycyny Doswiadczalnej (Online)
|March 12, 2013
PubMed

NKT cells are a heterogeneous subset of T lymphocytes that share surface markers and functional characteristics with both conventional T lymphocytes and natural killer cells. Most NKT cells express a semi-invariant T cell receptor that reacts with glycolipid antigens presented by the CD1d molecule on the surface of antigen-presenting cells. NKT cells can modulate the immune response against infectious agents, autoantigens, tumors, tissue grafts and allergens. NKT cells mediate the activities through their ability to express pro- and anti-inflammatory cytokines that influence the type and magnitude of the immune response. The manuscript summarizes current views on development of NKT cells as well as mechanisms and effects of their action.

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