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Updated: May 13, 2026
08:43
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
3,3,3-Trifluoro-2-hydr-oxy-2-(trifluoro-meth-yl)propionic acid
1Nelson Mandela Metropolitan University, Summerstrand Campus, Department of Chemistry, University Way, Summerstrand, PO Box 77000, Port Elizabeth, 6031, South Africa.
Acta Crystallographica. Section E, Structure Reports Online
|March 12, 2013
Summary
This study details the molecular structure of a perfluorinated hydroxy-isobutyric acid derivative. It reveals intramolecular hydrogen bonding and crystal packing into chains via intermolecular hydrogen bonds.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Perfluorinated organic compounds are important in materials science.
- Understanding molecular structure is key to predicting chemical properties.
Purpose of the Study:
- To characterize the molecular and crystal structure of a specific perfluorinated hydroxy-isobutyric acid derivative.
- To investigate the presence and role of hydrogen bonding in the compound.
Main Methods:
- Single-crystal X-ray diffraction was used to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and torsion angles provided structural insights.
Main Results:
- The molecule exhibits approximate Cs symmetry with a near-planar carboxyl group and C-OH moiety.
- An intramolecular O-H⋯O hydrogen bond was identified.
- Intermolecular O-H⋯O hydrogen bonds link molecules into chains along the a-axis in the crystal.
Conclusions:
- The study provides a detailed structural analysis of the perfluorinated compound.
- Hydrogen bonding plays a significant role in both intramolecular interactions and crystal packing.
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