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Effects in food-producing animals

    IARC Scientific Publications
    |March 13, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Mycotoxins in animal feed cause significant production losses. Early identification of mycotoxin involvement through outward signs aids farmers in minimizing adverse impacts and economic losses.

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    Area of Science:

    • Veterinary Toxicology
    • Animal Production Science
    • Food Safety

    Background:

    • Mycotoxins in animal feed have long been suspected in unexplained disease outbreaks.
    • Field manifestations of mycotoxicoses are often nonspecific and multifactorial.
    • Toxigenic molds were implicated in animal diseases before mycotoxins were chemically identified.

    Purpose of the Study:

    • To provide information for field identification of mycotoxin involvement in animal production problems.
    • To aid farmers in minimizing losses due to mycotoxin-induced diseases.
    • To enhance understanding of mycotoxin toxicokinetics and toxicology for effective interventions.

    Main Methods:

    • Review of historical field observations and scientific literature.
    • Analysis of chemical methods for mycotoxin detection in feed and tissues.
    • Correlation of mycotoxin exposure with dose-response relationships in farm animals.

    Main Results:

    • Established dose-response relationships for key mycotoxins (aflatoxins, fumonisins, ochratoxin A, deoxynivalenol, zearalenone, ergot alkaloids).
    • Identified reduced growth, decreased production, lower reproductive efficiency, and increased stress susceptibility as consequences.
    • Highlighted the importance of target organ effects in identifying specific mycotoxins.

    Conclusions:

    • Awareness of clinical signs is crucial for early mycotoxin detection.
    • Understanding toxicokinetics and toxicology aids in effective management strategies.
    • Field identification of mycotoxins empowers farmers to minimize economic losses.