Related Experiment Video

Updated: May 13, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

Advances in anticancer antibody-drug conjugates and immunotoxins

Franco Dosio, Barbara Stella, Sofia Cerioni

  • 1Dipartimento di Scienza e Tecnologia del Farmaco, University of Torino, v. P. Giuria 9, I-10125 Torino, Italy. franco.dosio@unito.it.

Recent Patents on Anti-Cancer Drug Discovery
|March 13, 2013
PubMed

Insights

Antibody-drug conjugates and immunotoxins offer targeted cancer therapy by delivering potent agents directly to tumor cells, minimizing side effects. Recent clinical trials show promising results, highlighting the advancement of these biopharmaceuticals.

Area of Science:

  • Biopharmaceuticals
  • Oncology
  • Drug Delivery

Background:

  • Antibody-delivered drugs and toxins are emerging cancer therapeutics.
  • They selectively target cancer cells with tumor-associated markers, reducing systemic toxicity.
  • Promising clinical trial results, especially in hematologic cancers, demonstrate their potential.

Purpose of the Study:

  • To review recent advances in antibody-drug conjugates and immunotoxins.
  • To discuss their mechanisms of action, conjugation, and purification processes.
  • To summarize clinical trial outcomes and novel technologies.

Main Methods:

  • Literature and patent review (up to February 2013).
  • Analysis of conjugation and purification techniques.
  • Compilation of clinical trial results for antibody-drug conjugates and immunotoxins.

Main Results:

  • Over twenty antibody-drug conjugates and eight immunotoxins are in clinical trials.
  • Several drugs have been recently approved, indicating therapeutic maturity.
  • Innovative technologies and novel agents are under development.

Conclusions:

  • Antibody-delivered therapies represent a mature and advancing approach to cancer treatment.
  • Continued development focuses on novel drugs, toxins, and delivery technologies.
  • These biopharmaceuticals show significant promise for improving cancer patient outcomes.

More Related Videos

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...