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Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury
M L Waintrub1, L S Terada, C J Beehler
1Webb-Waring Lung Institute, Department of Medicine, University of Colorado, Health Sciences Center, Denver 80262.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|April 1, 1990
Abstract:
Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.