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Updated: May 13, 2026

Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
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Motor assessment using the NIH Toolbox.

David B Reuben1, Susan Magasi, Heather E McCreath

  • 1Division of Geriatrics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. dreuben@mednet.ucla.edu

Neurology
|March 13, 2013
PubMed
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The NIH Toolbox now includes motor function tests for dexterity, strength, balance, locomotion, and endurance. These validated, low-cost measures assess neurological and behavioral function across ages 3 to 85.

Area of Science:

  • Neurology
  • Human Physiology
  • Biomedical Engineering

Background:

  • Motor function is crucial for daily life and reflects overall health.
  • It integrates multiple physiological systems, impacting quality of life.
  • Motor function is a key domain in the NIH Toolbox for assessing neurological and behavioral function.

Purpose of the Study:

  • To develop and validate motor function measures for the NIH Toolbox.
  • To identify key subdomains and candidate assessments for motor function.
  • To ensure measures are feasible, reliable, and valid across a wide age range (3-85 years).

Main Methods:

  • A three-stage developmental process: subdomain identification, feasibility pretesting, and criterion validation.
  • Inclusion of 340 healthy participants aged 3 to 85 years.

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A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation
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Related Experiment Videos

Last Updated: May 13, 2026

Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation
10:27

A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation

Published on: February 27, 2026

  • Literature review and expert input guided measure selection.

    • Main Results:

    • Five motor subdomains were identified: dexterity, strength, balance, locomotion, and endurance.
    • Validated, low-cost, and portable measures were recommended for each subdomain.
    • Specific measures include the 9-hole peg test, grip dynamometry, balance tests, and walk tests.

    Conclusions:

    • The NIH Toolbox now offers a comprehensive motor battery.
    • These measures provide reliable and valid assessments of motor function across the lifespan.
    • The selected tools are practical for widespread use in assessing neurological and behavioral health.