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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Related Experiment Video

Updated: May 13, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
12:19

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Autoimmunity and cancer.

M I Sara Achenza1, Carlo Selmi

  • 1Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Milan, Italy.

Asian Pacific Journal of Cancer Prevention : APJCP
|March 14, 2013
PubMed
Summary
This summary is machine-generated.

Autoimmune diseases and cancer share common pathogenic mechanisms, increasing cancer risk. This review examines shared factors and epidemiological evidence linking autoimmune conditions to cancer development.

Related Experiment Videos

Last Updated: May 13, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
12:19

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Area of Science:

  • Immunology and Oncology
  • Epidemiology of chronic diseases

Background:

  • The link between autoimmune diseases and cancer is clinically significant but complex.
  • Shared pathogenic mechanisms are implicated, yet direct causal proof is often lacking.
  • Accurate cancer risk assessment in autoimmune patients requires further investigation.

Purpose of the Study:

  • To critically review the evidence on shared mechanisms between autoimmune diseases and cancer.
  • To analyze the epidemiological data regarding cancer risk in individuals with autoimmune conditions.
  • To explore factors influencing the observed associations, including bias and susceptibility.

Main Methods:

  • Literature review of existing studies on autoimmune diseases and cancer.
  • Analysis of shared etiological factors and epidemiological data.
  • Critical evaluation of evidence for direct and indirect associations.

Main Results:

  • Shared pathways in pathogenesis suggest a biological link.
  • Factors like awareness bias and diagnosis latency complicate risk estimation.
  • Autoimmune phenomena can present as paraneoplastic syndromes, indicating an indirect association.

Conclusions:

  • Understanding shared mechanisms is crucial for managing cancer risk in autoimmune patients.
  • Further research is needed to establish direct causality and refine risk estimates.
  • Addressing biases and considering genetic/epigenetic factors are essential for a comprehensive view.