Evaluation of degradation kinetics for abamectin in formulations using a stability indicating method
Atul Awasthi1, Majid Razzak, Raida Al-Kassas
1School of Pharmacy, The University of Auckland, New Zealand.
Acta Pharmaceutica (Zagreb, Croatia)
|March 14, 2013
Summary
Abamectin (ABM) topical solutions showed maximum stability in glycerol formal, with degradation following first-order kinetics. This research provides a foundation for developing stable, non-aqueous ABM veterinary formulations.
Area of Science:
- Veterinary pharmacology
- Analytical chemistry
Background:
- Abamectin (ABM) is a widely used antiparasitic agent in veterinary medicine.
- Limited data exists on the stability of ABM in non-aqueous topical formulations.
Purpose of the Study:
- To evaluate the stability and kinetics of abamectin in a 1% topical veterinary solution.
- To identify optimal solvents for ABM topical formulations.
Main Methods:
- High-performance liquid chromatography (HPLC) was used to analyze ABM degradation.
- Samples were stressed at elevated temperatures (55°C and 70°C) for 8 weeks.
- The HPLC method was validated for accuracy, precision, linearity, and specificity.
Main Results:
- Abamectin degradation followed first-order kinetics.
- Maximum stability was observed in glycerol formal.
- Degradation varied significantly between solvents and was distinct from typical hydrolysis.
Conclusions:
- Glycerol formal is a promising solvent for developing stable topical abamectin formulations.
- The study provides critical data for designing effective and stable veterinary ABM products.
- Further research into non-aqueous ABM formulations is warranted.
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