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Updated: May 13, 2026

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
Published on: December 12, 2025
Influence of epididymitis on reproductive function
1Andrology Department of Research National Centre of Dermatologic and Sexually Transmitted Disorders, Ltd; Iv. Javakhishvili Tbilisi State University, Medical Faculty, Department of Dermatovenereology, Tbilisi, Georgia.
Abstract:
In our study 54 patients were diagnosed epididymitis caused by STI and in 6 (11.1%) cases inflammatory process spread on seminal vesicles which negatively affected the state of male reproductive function. After having unilateral epididymitis pathospermia developed in 76% of cases and infertility - in 55.6%. In patients who had unilateral acute epididymitis, infertility caused by urethritis of chlamidial aetiology developed in 70.4% of cases, infertility caused by urethritis of mycoplasmatic (ureaplasma) genesis - in 62.9% of cases and infertility caused by gonorrheal urethritis - in 29.6% of cases. At this moment following alterations of ejaculate are revealed: volume reduction, decrease in spermatozoid number, reduction of ability to move, increase in teratomatous forms, spermagglutination, etc. The best way for prevention of pathospermia and infertility is using modern and adequate treatment methods directed to maximally effective suppression of acute inflammatory process in epididymis and then restoration of its functions.
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