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Updated: May 13, 2026

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
Published on: August 16, 2024
NK cell-released exosomes: Natural nanobullets against tumors
1Unit of Antitumor Drugs; Department of Therapeutic Research and Medicines Evaluation; Istituto Superiore di Sanità; Rome, Italy.
Abstract:
We have recently reported that human natural killer (NK) cells release exosomes that express both NK-cell markers and cytotoxic molecules. Similar results were obtained with circulating exosomes from human healthy donors. Both NK-cell derived and circulating exosomes exerted a full functional activity and killed both tumor and activated immune cells. These findings indicate that NK-cell derived exosomes might constitute a new promising therapeutic tool.
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