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Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
Alexander Pedroza-Gonzalez1, Jaap Kwekkeboom, Dave Sprengers
1Department of Gastroenterology and Hepatology; Erasmus MC-University Medical Center; Rotterdam, The Netherlands.
Oncoimmunology
|March 14, 2013
Abstract:
Recently, we reported the accumulation of CD4+FOXP3+ regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression mediated by TiTregs.
