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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
[Mini-Mental State Examination in geriatrics : An evaluation of diagnostic quality]
S Beyermann1, R H Trippe, A A Bähr
1Zentrum für Geriatrie und Orthopädie, Otto-Fricke-Krankenhaus Paulinenberg GmbH, Martha-von-Opel-Weg 34, 65307, Bad Schwalbach, Deutschland, Stefanie.Beyermann@otto-fricke-krankenhaus.de.
Background:
Several studies have identified moderate reliability and validity for the Mini-Mental State Examination (MMSE). Some researchers showed the superiority of other dementia screening tests over the MMSE considering the test quality criteria. The aim of this study was the evaluation of MMSE, especially in the area of geriatrics.
Patients And Methods:
MMSE and DemTect were carried out with 154 geriatric patients: 71 persons without cognitive impairment and 83 persons without delirium showed cognitive impairments as revealed by the DemTect. In addition, we also applied the Clock-Drawing-Test (CDT), Reisberg-Scale, Geriatric Depression-Scale (GDS, 15-item version) and the Confusion-Assessment-Method (CAM).
Results:
According to the multitrait-multimethod approach, MMSE's convergent and divergent validity is similar to that of the DemTect. Both tests correlate only moderately with Spearman (r = 0.609) and revealed similar results for dementia in 57.1 % of the patients. MMSE showed low reliability and moderate reliability (Cronbach's α = 0.82) when ten items with low discriminatory power were excluded from the total test score. Difficulty of all items is only moderate (p = 0.86) and only eight items of the MMSE showed good test difficulty.
Conclusion:
All in all, DemTect and MMSE are not interchangeable. The MMSE estimates the average cognitive impairment of patients as considerably less pronounced than the DemTect. MMSE is, thus, not an instrument that would be recommended for the identification of mild cognitive impairment. In this case, tests with higher reliability and validity should be used.
Insights
The Mini-Mental State Examination (MMSE) shows moderate reliability but is less sensitive than DemTect for detecting mild cognitive impairment in geriatric patients. Higher validity tests are recommended for this population.
Area of Science:
- Geriatric Medicine
- Neuropsychology
- Cognitive Assessment
Background:
- The Mini-Mental State Examination (MMSE) has demonstrated moderate reliability and validity in previous studies.
- Concerns exist regarding the MMSE's test quality criteria compared to other dementia screening tools.
- This study specifically evaluates the MMSE's utility in a geriatric population.
Purpose of the Study:
- To evaluate the Mini-Mental State Examination (MMSE) performance in geriatric patients.
- To compare the MMSE with the DemTect and other cognitive assessment tools in this demographic.
- To assess the reliability and validity of the MMSE for identifying cognitive impairment in the elderly.
Main Methods:
- 154 geriatric patients were assessed using the MMSE and DemTect.
- Participants included 71 individuals without cognitive impairment and 83 with cognitive impairments (excluding delirium).
- Additional assessments included the Clock-Drawing-Test (CDT), Reisberg Scale, Geriatric Depression-Scale (GDS), and Confusion Assessment Method (CAM).
Main Results:
- MMSE and DemTect exhibited similar convergent and divergent validity.
- Spearman correlation (r=0.609) indicated a moderate agreement between MMSE and DemTect, with similar dementia results in 57.1% of patients.
- MMSE demonstrated moderate reliability (Cronbach's α=0.82) after excluding ten low-discriminatory items; item difficulty was moderate overall.
Conclusions:
- The MMSE and DemTect are not interchangeable for cognitive assessment.
- MMSE tends to underestimate the average cognitive impairment compared to DemTect.
- MMSE is not recommended for identifying mild cognitive impairment; tests with higher reliability and validity are preferred for this purpose.
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