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Related Experiment Video

Updated: May 13, 2026

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling
05:23

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

Published on: May 31, 2024

Acceleration-selective arterial spin labeling.

Sophie Schmid1, Eidrees Ghariq, Wouter M Teeuwisse

  • 1C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.

Magnetic Resonance in Medicine
|March 14, 2013
PubMed
Summary
This summary is machine-generated.

A novel acceleration-selective ASL (AccASL) method images brain perfusion by detecting flowing spin acceleration, minimizing venous signal contamination. AccASL differentiates arterial and venous signals in one module, unlike VSASL, and is cerebral blood volume weighted.

Keywords:
acceleration selectivearterial spin labelingperfusion imagingspatially nonselective labeling

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Area of Science:

  • Magnetic Resonance Imaging
  • Neuroimaging
  • Physiology

Background:

  • Arterial Spin Labeling (ASL) is a non-invasive MRI technique for assessing cerebral blood flow.
  • Existing ASL methods like velocity-selective ASL (VSASL) can suffer from venous signal contamination.
  • Distinguishing arterial and venous signals is crucial for accurate perfusion imaging.

Purpose of the Study:

  • Introduce and validate a new ASL technique, acceleration-selective ASL (AccASL), for improved brain perfusion imaging.
  • Demonstrate AccASL's ability to minimize venous signal contamination.
  • Compare AccASL with existing ASL methods and assess its functional MRI feasibility.

Main Methods:

  • Developed AccASL using acceleration-encoded magnetic resonance angiography principles with motion-sensitizing gradients in a T2-preparation module.
  • Implemented AccASL with spatially nonselective labeling, exploiting higher arterial spin acceleration in microvasculature.
  • Tested AccASL in healthy volunteers, comparing it with VSASL and pseudo-continuous ASL (PCASL), and assessing functional MRI performance.

Main Results:

  • AccASL successfully imaged brain perfusion with significantly reduced venous signal contamination compared to single-module VSASL.
  • AccASL demonstrated comparable signal-to-noise ratio to PCASL.
  • Robust visual cortex activation was observed during functional MRI using AccASL.

Conclusions:

  • AccASL is a novel ASL technique capable of imaging brain perfusion with minimal venous contamination.
  • AccASL offers a single-module solution for differentiating arterial and venous signals, primarily reflecting cerebral blood volume.
  • AccASL shows promise for accurate perfusion imaging and functional MRI applications.