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Cell type specific gene delivery by lentiviral vectors: New options in immunotherapy
Qi Zhou1, Christian J Buchholz
1Molecular Biotechnology and Gene Therapy; Paul-Ehrlich-Institut; Langen, Germany.
Oncoimmunology
|March 14, 2013
Abstract:
Many cells of the immune system are defined by distinct surface markers, which can be used to restrict gene delivery exclusively to a cell type of choice. This article explains recent findings about a CD8-specific vector that enhances the killing of tumor cells in TCR-based gene transfer strategies.
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