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Related Experiment Video

Updated: May 13, 2026

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
04:05

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Published on: July 5, 2024

Transvesical NOTES: survival study in porcine model.

Jasneet Singh Bhullar1, Gokulakkrishna Subhas, Aditya Gupta

  • 1Department of Surgery, Providence Hospital and Medical Centers, Southfield, MI, USA. drjsbhullar@gmail.com

JSLS : Journal of the Society of Laparoendoscopic Surgeons
|March 15, 2013
PubMed
Summary

A novel transvesical technique for natural orifice transluminal endoscopic surgery (NOTES) offers a safe and effective approach. This method ensures good access and closure, minimizing risks for future human application.

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Area of Science:

  • Minimally Invasive Surgery
  • Gastroenterology
  • Urology

Background:

  • Natural orifice transluminal endoscopic surgery (NOTES) lacks established optimal access routes.
  • The transvesical approach offers a clean entry but faces challenges in safe urinary bladder closure.
  • A new technique for a pure transvesical NOTES approach was developed.

Purpose of the Study:

  • To develop and evaluate a novel technique for safe urinary bladder closure in transvesical NOTES.
  • To assess the feasibility and safety of a pure transvesical NOTES approach.
  • To overcome risks associated with previous transvesical NOTES methods.

Main Methods:

  • A transvesical endoscopic cystotomy was performed using a flexible cystoscope in four female piglets.
  • Diagnostic peritoneoscopy with biopsies and hemostasis was conducted.

Related Experiment Videos

Last Updated: May 13, 2026

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
04:05

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs

Published on: July 5, 2024

  • A Vicryl loop was used for bladder incision closure, followed by necropsy after two weeks.

    • Main Results:

    • No bowel injuries were observed in any of the study animals.
    • Satisfactory bladder closure was achieved in two pigs, with partial closure in one.
    • Necropsy revealed healed cystotomy incisions, absence of intra-abdominal adhesions, and no postoperative pain or distress.

    Conclusions:

    • The new endoscopic cystotomy technique effectively addresses risks of bowel injury.
    • The transvesical route provides excellent spatial orientation and access for NOTES procedures.
    • The observed lack of intraperitoneal changes suggests potential safety for human application.