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[Recent studies on PI3K/AKT/mTOR signaling pathway in hematopoietic stem cells]
Ying-Chi Zhang1, Tao Cheng, Wei-Ping Yuan
1Chinese Academy of Medical Sciences, Tianjin, China.
Abstract:
PI3K/AKT/mTOR signaling pathway plays an essential role in the growth, proliferation and survival of various type of cells and also hematopoietic stem cells (HSC). Aberrant activation of PI3K/AKT/mTOR signaling pathway leads to exhaustion of HSC, while the inhibition of PI3K/AKT/mTOR signaling pathway results in blocking of B cell differentiation. This article reviews the latest advances on the role of key components involved in the PI3K/AKT/mTOR signaling pathway, including PI3K, AKT, mTOR, FoxO and GSK-3 in HSC.
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