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Nuclear Transmutation03:20

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...
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Updated: May 13, 2026

A 100 KW Class Applied-field Magnetoplasmadynamic Thruster
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New magic bullets can hit more than one target.

Nicolas Fischer1

  • 1Novimmune SA, 14 ch. des Aulx, Ch-1228 Plan-les-Ouates, Switzerland +41 22 5935144 ; +41 22 5935139 ; nfischer@novimmune.com.

Expert Opinion on Drug Discovery
|March 15, 2013
PubMed
Summary

Targeting multiple antigens with engineered antibodies offers a promising strategy to overcome limitations of single-target therapies for complex diseases. This approach aims to enhance therapeutic efficacy by addressing multiple disease drivers simultaneously.

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Area of Science:

  • Immunology
  • Biotechnology
  • Drug Discovery

Background:

  • Monoclonal antibodies are successful therapeutics for various diseases.
  • Single-antigen targeting may be insufficient for certain complex diseases.
  • The therapeutic efficacy of current monoclonal antibodies can be limited.

Purpose of the Study:

  • To explore strategies for achieving multiple antigen targeting with antibodies.
  • To investigate the benefits and challenges of multi-antigen targeting in therapeutic settings.
  • To review innovative antibody engineering approaches for multi-targeting.

Main Methods:

  • Review of antibody engineering techniques.
  • Analysis of multi-antigen targeting strategies.
  • Evaluation of advantages and challenges in antibody development.

Main Results:

  • Multiple antigen targeting can be achieved through various antibody engineering methods.
  • Innovative molecular formats have been developed to enable multi-targeting.
  • These approaches present both opportunities and development hurdles.

Conclusions:

  • Multi-antigen targeting represents a significant advancement in antibody therapeutics.
  • Further research and development are needed to optimize engineered antibodies for multi-targeting.
  • This strategy holds potential for improved treatment of diseases requiring broader molecular intervention.