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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease ll: Pathophysiology01:24

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

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Ole Isacson: Development of New Therapies for Parkinson's Disease
23:53

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Published on: April 29, 2007

Protagonists with Parkinson's disease.

Joost Haan1

  • 1Department of Neurology, Rijnland Hospital and Leiden University Medical Centre, Leiderdorp/Leiden, The Netherlands. jhaan@rijnland.nl

Frontiers of Neurology and Neuroscience
|March 15, 2013
PubMed
Summary
This summary is machine-generated.

This chapter explores Parkinson's disease (PD) in literature, examining how authors use motor and non-motor symptoms to convey complex themes. Fictional portrayals offer unique insights into the lived experience of Parkinson's disease.

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Area of Science:

  • Neurology
  • Literary Studies
  • Medical Humanities

Background:

  • Parkinson's disease (PD) is a progressive neurodegenerative disorder.
  • PD presents with diverse motor and non-motor symptoms, impacting cognition and mood.
  • Literary narratives often explore complex human conditions, including chronic illness.

Purpose of the Study:

  • To analyze the portrayal of Parkinson's disease in selected literary works.
  • To examine how authors utilize PD symptoms to develop characters and themes.
  • To highlight the intersection of medical humanities and literary analysis.

Main Methods:

  • Qualitative analysis of literary texts.
  • Character study of protagonists with Parkinson's disease.
  • Thematic analysis of narrative elements related to PD symptoms.

Main Results:

  • Authors frequently employ PD symptoms like rigidity, cognitive decline, and hallucinations metaphorically.
  • Literary depictions reflect themes of inevitability, confusion, and altered perception.
  • Specific authors like John Updike and J.M. Coetzee offer nuanced portrayals of PD.

Conclusions:

  • Literature provides a valuable lens for understanding the multifaceted experience of Parkinson's disease.
  • Fictional representations can enhance public awareness and empathy towards PD patients.
  • The study underscores the role of narrative in exploring chronic illness and its societal impact.