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[Clinico-pathomorphologic evaluation of changes of the interventricular heart septum in hypertrophic cardiomyopathy]
Insights
This study compared hypertrophic cardiomyopathy hearts to control hearts, revealing varied ventricular septum changes. Echocardiography findings only partially matched postmortem results, highlighting diagnostic discrepancies.
Area of Science:
- Cardiology
- Pathology
- Medical Imaging
Background:
- Hypertrophic cardiomyopathy (HCM) is a significant cardiac condition.
- Understanding ventricular septum morphology is crucial for diagnosing HCM.
- Echocardiography is a primary diagnostic tool for HCM.
Purpose of the Study:
- To investigate changes in the ventricular septum in hypertrophic cardiomyopathy.
- To evaluate the diagnostic significance of echocardiographic findings against postmortem data.
- To identify factors contributing to discrepancies between echocardiographic and pathological diagnoses.
Main Methods:
- Comparative analysis of 20 HCM hearts and 20 control hearts.
- Utilized postmortem cardioventriculography, coronarography, and cardiometry.
- Employed target histotopographic techniques for detailed analysis.
Main Results:
- Identified diverse patterns of ventricular septum hypertrophy (even, midventricular, wave-line, midapical, apical).
- Complete concordance between echocardiographic and pathomorphological findings occurred in 30% of cases.
- Partial concordance was observed in 35%, and discordance in 35% of cases.
Conclusions:
- Significant variations exist in ventricular septum morphology in HCM.
- Echocardiography demonstrates limitations in fully capturing pathomorphological changes in HCM.
- Factors causing echopathomorphological dissociations require further investigation.
Abstract:
A complex study was made of 20 hearts from patients who had died from hypertrophic cardiomyopathy and 20 matched control hearts with a view to detecting changes of the ventricular septum and to ascertaining the significance of echocardiographic diagnostic information. Postmortem cardioventriculography, coronarography, volume-mass and planimetric cardiometry, target histopographic techniques, were applied. Various ventricular septum hypertrophies, such as even, midventricular, wave-line, midapical and apical, were identified. A complete coincidence was found between the cardiographic and pathomorphological diagnostic findings in 6 (30%) cases, a partial one was seen in 7 (35%), and incoincidence was also observed in 7 (35%) cases. The paper provides the major factors underlying echopathomorphological dissociations.