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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Gross Anatomy of Bone01:17

Gross Anatomy of Bone

The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

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Related Experiment Video

Updated: May 13, 2026

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
04:32

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

Gorham's disease: the disappearing bone.

Rong-Hsin Yang1, Paul Chih-Hsueh Chen, Cheng-Pei Chang

  • 1Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. ronghsin.yang@gmail.com

Clinical Nuclear Medicine
|March 15, 2013
PubMed
Summary
This summary is machine-generated.

Gorham's disease, a rare vascular disorder, presents variably. Early diagnosis requires high clinical suspicion and recognizing key imaging and biopsy findings for effective management.

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Last Updated: May 13, 2026

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
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Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Area of Science:

  • Rare diseases
  • Vascular disorders
  • Bone pathology

Background:

  • Gorham's disease is a rare condition involving vascular channel proliferation.
  • Clinical presentation varies significantly based on the affected anatomical site.
  • Accurate diagnosis necessitates a high index of clinical suspicion.

Observation:

  • A 31-year-old male presented with symptoms suggestive of Gorham's disease.
  • Imaging revealed active bone destruction in the thoracic and lumbar spine.
  • Complete absence of the left lower rib cage was noted.

Findings:

  • Nuclear scintigraphy and CT scans identified extensive bone destruction.
  • Histopathological examination via biopsy confirmed Gorham's disease.
  • Distinctive radiologic and histopathologic features are crucial for diagnosis.

Implications:

  • Early recognition of Gorham's disease is vital for timely intervention.
  • Understanding the variable presentation aids in differential diagnosis.
  • Advanced imaging and biopsy are key to confirming the diagnosis and guiding treatment.