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Updated: May 13, 2026

Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
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Epithelial cell adhesion molecule (EpCAM) regulates claudin dynamics and tight junctions

Chuan-Jin Wu1, Poonam Mannan, Michael Lu

  • 1Dermatology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892-1908, USA.

The Journal of Biological Chemistry
|March 15, 2013
PubMed
Summary

Epithelial cell adhesion molecule (EpCAM) regulates tight junction (TJ) function by controlling claudin protein levels. EpCAM knockdown enhances TJ formation and stability, suggesting a novel therapeutic target for epithelial barrier disorders.

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